J. Wityak: search on Z-Library

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1

Durkheim's Non-Social Facts about Primitives and Women

Nancy L. WITYAK, Ruth A. WALLACE

Journal:

Sociological Inquiry

Year:

1981

Language:

english

File:

PDF, 608 KB

english, 1981

2

Beyond U0126. Dianion chemistry leading to the rapid synthesis of a series of potent MEK inhibitors

John Wityak, Frank W. Hobbs, Daniel S. Gardner, Joseph B. Santella III, Joseph J. Petraitis, Jung-Hui Sun, Margaret F. Favata, Andrea J. Daulerio, Kurumi Y. Horiuchi, Robert A. Copeland, Peggy A. Sche

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 203 KB

english, 2004

3

Noninvasive Relative Quantification of [11C]ABP688 PET Imaging in Mice Versus an Input Function Measured Over an Arteriovenous Shunt

Verhaeghe, Jeroen, Bertoglio, Daniele, Kosten, Lauren, Thomae, David, Verhoye, Marleen, Van Der Linden, Annemie, Wyffels, Leonie, Stroobants, Sigrid, Wityak, John, Dominguez, Celia, Mrzljak, Ladislav,

Journal:

Frontiers in Neurology

Year:

2018

Language:

english

File:

PDF, 13.76 MB

english, 2018

4

ChemInform Abstract: Discovery of Potent Isoxazoline Glycoprotein IIb/IIIa Receptor Antagonists.

J. WITYAK, T. M. SIELECKI, D. J. PINTO, G. EMMETT, J. Y. SZE, J. LIU, A. E. TOBIN, S. WANG, B. JIANG, P. MA, S. A. MOUSA, R. R. WEXLER, R. E. OLSON

Journal:

Year:

1997

File:

PDF, 31 KB

1997

5

ChemInform Abstract: Biaryl Substituted Alkylboronate Esters as Thrombin Inhibitors.

M. L. QUAN, J. WITYAK, C. DOMINGUEZ, J. V. DUNCIA, C. A. KETTNER, C. D. ELLIS, A. Y. LIAUW, J. M. PARK, J. B. SANTELLA, R. M. KNABB, M. J. THOOLEN, P. C. WEBER, R. R. WEXLER

Journal:

Year:

1997

File:

PDF, 27 KB

1997

6

ChemInform Abstract: Isoxazoline GPIIb/IIIa Antagonists Bearing a Phosphoramidate

John Wityak, A. Ewa Tobin, Shaker A. Mousa, Ruth R. Wexler, Richard E. Olson

Journal:

Year:

1999

File:

PDF, 27 KB

1999

7

ChemInform Abstract: Isoxazolines as Potent Antagonists of the Integrin αvβ3.

John Wityak, et al. et al.

Journal:

Year:

2000

File:

PDF, 39 KB

2000

8

ChemInform Abstract: Ring Constrained Analogues of β-Alanine-Containing GPIIb/IIIa Receptor Antagonists.

Thais M. Sielecki, John Wityak, Jie Liu, Shaker A. Mousa, Martin Thoolen, Ruth R. Wexler, Richard E. Olson

Journal:

Year:

2000

File:

PDF, 31 KB

2000

9

Discovery and Initial SAR of 2-Amino-5-carboxamidothiazoles as Inhibitors of the Src-Family Kinase p56Lck.

John Wityak, Jagabandhu Das, et al. et al.

Journal:

Year:

2004

File:

PDF, 97 KB

2004

10

A versatile synthesis of C-5 labeled ornithines

John Wityak, Venkatapuram A. Palaniswamy, Steven J. Gould

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

1985

Language:

english

File:

PDF, 367 KB

english, 1985

11

Biosynthesis of streptothricin F: 7. The fate of the arginine hydrogens

Steven J. Gould, Junning Lee, John Wityak

Journal:

Bioorganic Chemistry

Year:

1991

Language:

english

File:

PDF, 1.19 MB

english, 1991

12

Synthesis and antiplatelet activity of DMP 757 analogs

John Wityak, John M. Fevig, Sharon A. Jackson, Alexander L. Johnson, Shaker A. Mousa, Anju Parthasarathy, Gregory J. Wells, William F. DeGrado, Ruth R. Wexler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 208 KB

english, 1995

13

Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56Lck

John Wityak, Jagabandhu Das, Robert V. Moquin, Zhongqi Shen, James Lin, Ping Chen, Arthur M. Doweyko, Sidney Pitt, Suhong Pang, Ding Ren Shen, Qiong Fang, Henry F. de Fex, Gary L. Schieven, Steven B.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 224 KB

english, 2003

14

Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56Lck inhibitors

Ping Chen, Derek Norris, Jagabandhu Das, Steven H. Spergel, John Wityak, Leslie Leith, Rulin Zhao, Bang-Chi Chen, Sidney Pitt, Suhong Pang, Ding Ren Shen, Rosemary Zhang, Henry F. De Fex, Arthur M. Do

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 352 KB

english, 2004

15

3,4,5-Trisubstituted isoxazoles as novel PPARδ agonists. Part 2

Robert Epple, Mihai Azimioara, Ross Russo, Yongping Xie, Xing Wang, Christopher Cow, John Wityak, Don Karanewsky, Badry Bursulaya, Andreas Kreusch, Tove Tuntland, Andrea Gerken, Maya Iskandar, Enrique

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 193 KB

english, 2006

16

Ring constrained analogues of β-alanine-containing GPIIb/IIIa receptor antagonists

Thais M Sielecki, John Wityak, Jie Liu, Shaker A Mousa, Martin Thoolen, Ruth R Wexler, Richard E Olson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 126 KB

english, 2000

17

Synthesis and SAR of novel imidazoquinoxaline-Based Lck inhibitors: improvement of cell potency

Ping Chen, Edwin J. Iwanowicz, Derek Norris, Henry H. Gu, James Lin, Robert V. Moquin, Jagabandhu Das, John Wityak, Steven H. Spergel, Henry de Fex, Suhong Pang, Sydney Pitt, Ding Ren Shen, Gary L. Sc

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 117 KB

english, 2002

18

Molecular design, synthesis, and structure–Activity relationships leading to the potent and selective p56lck inhibitor BMS-243117

Jagabandhu Das, James Lin, Robert V. Moquin, Zhongqi Shen, Steven H. Spergel, John Wityak, Arthur M. Doweyko, Henry F. DeFex, Qiong Fang, Suhong Pang, Sidney Pitt, Ding Ren Shen, Gary L. Schieven, Joe

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 228 KB

english, 2003

19

Discovery of 2-amino-heteroaryl-benzothiazole-6-anilides as potent p56lck inhibitors

Jagabandhu Das, Robert V. Moquin, James Lin, Chunjian Liu, Arthur M. Doweyko, Henry F. DeFex, Qiong Fang, Suhong Pang, Sidney Pitt, Ding Ren Shen, Gary L. Schieven, Joel C. Barrish, John Wityak

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 204 KB

english, 2003

20

Biaryl substituted alkylboronate esters as thrombin inhibitors

M.L. Quan, J. Wityak, C. Dominguez, J.V. Duncia, C.A. Kettner, C.D. Ellis, A.Y. Liauw, J.M. Park, J.B. Santella, R.M. Knabb, M.J. Thoolen, P.C. Weber, R.R. Wexler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 266 KB

english, 1997

21

Bisbenzamidine isoxazoline derivatives as factor Xa inhibitors

M.L. Quan, J.R. Pruitt, C.D. Ellis, A.Y. Liauw, R.A. Galemmo Jr., P.F.W. Stouten, J. Wityak, R.M. Knabb, M.J. Thoolen, P.C. Wong, R.R. Wexler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 264 KB

english, 1997

22

MEK inhibitors: The chemistry and biological activity of U0126, its analogs, and cyclization products

John V. Duncia, Joseph B. Santella III, C.Anne Higley, William J. Pitts, John Wityak, William E. Frietze, F.Wayne Rankin, Jung-Hui Sun, Richard A. Earl, A.Christine Tabaka, Christopher A. Teleha, Karl

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 361 KB

english, 1998

23

Isoxazoline GPIIb/IIIa antagonists bearing a phosphoramidate

John Wityak, A.Ewa Tobin, Shaker A. Mousa, Ruth R. Wexler, Richard E. Olson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 218 KB

english, 1999

24

Identification of chemokine receptor CCR4 antagonist

Ashok V. Purandare, Aiming Gao, Honghe Wan, John Somerville, Christine Burke, Carrie Seachord, Wayne Vaccaro, John Wityak, Michael A. Poss

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 114 KB

english, 2005

25

3,4,5-Trisubstituted isoxazoles as novel PPARδ agonists: Part 1

Robert Epple, Ross Russo, Mihai Azimioara, Christopher Cow, Yongping Xie, Xing Wang, John Wityak, Don Karanewsky, Andrea Gerken, Maya Iskandar, Enrique Saez, H. Martin Seidel, Shin-Shay Tian

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 131 KB

english, 2006

26

Discovery and initial SAR of imidazoquinoxalines as inhibitors of the Src-family kinase p56Lck

Ping Chen, Derek Norris, Edwin J. Iwanowicz, Steven H. Spergel, James Lin, Henry H. Gu, Zhongqi Shen, John Wityak, Tai-An Lin, Suhong Pang, Henry F. De Fex, Sidney Pitt, Ding Ren Shen, Arthur M. Dowey

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 138 KB

english, 2002

27

Orally Active Isoxazoline GPIIb/IIIa Antagonists

Shaker A. Mousa, John Wityak

Journal:

Cardiovascular Therapeutics

Year:

1998

Language:

english

File:

PDF, 844 KB

english, 1998

28

Discovery of an Orally Active Series of Isoxazoline Glycoprotein IIb/IIIa Antagonists

Xue, Chu-Biao, Wityak, John, Sielecki, Thais M., Pinto, Donald J., Batt, Douglas G., Cain, Gary A., Sworin, Michael, Rockwell, Arlene L., Roderick, John J., Wang, Shuaige

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 789 KB

english, 1997

29

Orally Active Isoxazoline Glycoprotein IIb/IIIa Antagonists with Extended Duration of Action

Olson, Richard E., Sielecki, Thais M., Wityak, John, Pinto, Donald J., Batt, Douglas G., Frietze, William E., Liu, Jie, Tobin, A. Ewa, Orwat, Michael J., Di Meo, Susan V.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 365 KB

english, 1999

30

Discovery of 4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl- N -propylpyrrolo[1,2- f ][1,2,4]triazine-6-carboxamide (BMS-582949), a Clinical p38α MAP Kinase Inhibitor for the Treatment of Inflammatory Diseases

Liu, Chunjian, Lin, James, Wrobleski, Stephen T., Lin, Shuqun, Hynes, John, Wu, Hong, Dyckman, Alaric J., Li, Tianle, Wityak, John, Gillooly, Kathleen M., Pitt, Sidney, Shen, Ding Ren, Zhang, Rosemary

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.00 MB

english, 2010

31

Novel Bisaryl Substituted Thiazoles and Oxazoles as Highly Potent and Selective Peroxisome Proliferator-Activated Receptor δ Agonists

Epple, Robert, Cow, Christopher, Xie, Yongping, Azimioara, Mihai, Russo, Ross, Wang, Xing, Wityak, John, Karanewsky, Donald S., Tuntland, Tove, Nguyêñ-Trân, Vân T. B., Cuc Ngo, Cara, Huang, David,

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.63 MB

english, 2010

32

5-Cyanopyrimidine Derivatives as a Novel Class of Potent, Selective, and Orally Active Inhibitors of p38α MAP Kinase

Liu, Chunjian, Wrobleski, Stephen T., Lin, James, Ahmed, Gulzar, Metzger, Axel, Wityak, John, Gillooly, Kathleen M., Shuster, David J., McIntyre, Kim W., Pitt, Sidney, Shen, Ding Ren, Zhang, Rosemary

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 297 KB

english, 2005

33

N-Acylthiadiazolines, a New Class of Liver X Receptor Agonists with Selectivity for LXRβ

Molteni, Valentina, Li, Xiaolin, Nabakka, Juliet, Liang, Fang, Wityak, John, Koder, Alan, Vargas, Leo, Romeo, Russell, Mitro, Nico, Mak, Puiying A., Seidel, H. Martin, Haslam, Jennifer A., Chow, Donal

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 153 KB

english, 2007

34

Imidazoquinoxaline Src-Family Kinase p56 Lck Inhibitors: SAR, QSAR, and the Discovery of ( S )- N -(2-Chloro-6-methylphenyl)-2-(3-methyl-1-piperazinyl)imidazo- [1,5- a ]pyrido[3,2- e ]pyrazin-6-amine (BMS-279700) as a Potent and Orally Active Inhibitor with Excellent in Vivo Antiinflammatory Activity

Chen, Ping, Doweyko, Arthur M., Norris, Derek, Gu, Henry H., Spergel, Steven H., Das, Jagabundhu, Moquin, Robert V., Lin, James, Wityak, John, Iwanowicz, Edwin J., McIntyre, Kim W., Shuster, David J.,

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 370 KB

english, 2004

35

The Discovery of Potent Isoxazoline Glycoprotein IIb/IIIa Receptor Antagonists

Wityak, John, Sielecki, Thais M., Pinto, Donald J., Emmett, George, Sze, Jean Y., Liu, Jie, Tobin, A. Ewa, Wang, Shuaige, Jiang, Biao, Ma, Philip, Mousa, Shaker A., Olson, Richard E., Wexler, Ruth R.

Journal:

Journal of Medicinal Chemistry

Year:

1997

File:

PDF, 22 KB

1997

36

A 1,3-dipolar cycloaddition route to the 3(R)- and 3(S)-hydroxy-2(S)-arginines

Wityak, John, Gould, Steven J., Hein, Scott J., Keszler, Douglas A.

Journal:

Journal of Organic Chemistry

Year:

1987

Language:

english

File:

PDF, 673 KB

english, 1987

37

Discovery of Potent Isoxazoline Glycoprotein IIb/IIIa Receptor Antagonists

Wityak, John, Sielecki, Thais M., Pinto, Donald J., Emmett, George, Sze, Jean Y., Liu, Jie, Tobin, A. Ewa, Wang, Shuaige, Jiang, Biao, Ma, Philip, Mousa, Shaker A., Wexler, Ruth R., Olson, Richard E.

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 435 KB

english, 1997

38

Synthesis of Thrombin Inhibitor DuP 714

Wityak, John, Earl, Richard A., Abelman, Matthew M., Bethel, Yvonne B., Fisher, Barbara N., Kauffman, Goss S., Kettner, Charles A., Ma, Philip, McMillan, Janice L.

Journal:

Journal of Organic Chemistry

Year:

1995

Language:

english

File:

PDF, 732 KB

english, 1995

39

SAR Development of Lysine-Based Irreversible Inhibitors of Transglutaminase 2 for Huntington's Disease

Wityak, John, Prime, Michael E., Brookfield, Frederick A., Courtney, Stephen M., Erfan, Sayeh, Johnsen, Siw, Johnson, Peter D., Li, Marie, Marston, Richard W., Reed, Laura, Vaidya, Darshan, Schaertl,

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 384 KB

english, 2012

40

Synthesis of 1,3-Diynes Using Palladium-Copper Catalysis

Wityak, John, Chan, John B.

Journal:

Synthetic Communications

Year:

1991

Language:

english

File:

PDF, 128 KB

english, 1991

41

Isoxazolines as Potent Antagonists of the Integrin α v β 3

Pitts, William J., Wityak, John, Smallheer, Joanne M., Tobin, A. Ewa, Jetter, James W., Buynitsky, Jennifer S., Harlow, Patricia P., Solomon, Kimberly A., Corjay, Martha H., Mousa, Shaker A., Wexler,

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 275 KB

english, 2000

42

Erratum

Schaertl, S., Prime, M., Wityak, J., Dominguez, C., Munoz-Sanjuan, I., Pacifici, R.

Journal:

Journal of Biomolecular Screening

Year:

2010

Language:

english

File:

PDF, 120 KB

english, 2010

43

Lead Optimization toward Proof-of-Concept Tools for Huntington’s Disease within a 4-(1 H -Pyrazol-4-yl)pyrimidine Class of Pan-JNK Inhibitors

Wityak, John, McGee, Kevin F., Conlon, Michael P., Song, Ren Hua, Duffy, Bryan C., Clayton, Brent, Lynch, Michael, Wang, Gwen, Freeman, Emily, Haber, James, Kitchen, Douglas B., Manning, David D., Ism

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.28 MB

english, 2015

44

A Profiling Platform for the Characterization of Transglutaminase 2 (TG2) Inhibitors

Schaertl, S., Prime, M., Wityak, J., Dominguez, C., Munoz-Sanjuan, I., Pacifici, R. E., Courtney, S., Scheel, A., Macdonald, D.

Journal:

Journal of Biomolecular Screening

Year:

2010

Language:

english

File:

PDF, 571 KB

english, 2010

45

M20 Activation Of The Trkb Receptor Pathway Using A Novel Monoclonal Antibody Agonist: Implications For The Treatment Of Huntington's Disease

Carty, N., Schmidt, L., Bursow, G., Schwagarus, T., Graff, C., Damrath, E., Kuhlbrodt, K., Kohler, M., Koeplin, S., Salomon, K., Jager, S., Gemkow, M., von der Kammer, H., Wityak, J., Munoz-Sanjuan, I

Journal:

Journal of Neurology Neurosurgery & Psychiatry

Year:

2014

Language:

english

File:

PDF, 72 KB

english, 2014

46

ChemInform Abstract: A 1,3-Dipolar Cycloaddition Route to the 3(R)- and 3(S)-Hydroxy-(2S)arginines.

WITYAK, J., GOULD, S. J., HEIN, S. J., KESZLER, D. A.

Journal:

Year:

1987

File:

PDF, 144 KB

1987

47

Novel nonpeptide antiplatelet glycoprotein llb/llla receptor antagonist, DMP754

Mousa, Shaker A., Forsythe, Mark, Lorelli, William, Bozarth, Jeffrey, Xue, Chu-Biao, Wityak, John, Sielecki, Thais M., Olson, Rick E., DeGrado, William, Kapil, Ram, Hussain, Munir, Wexler, Ruth, Thool

Journal:

Coronary Artery Disease

Year:

1996

File:

PDF, 506 KB

1996

48

Longitudinal microPET imaging of the zQ175 mouse model of Huntington's disease shows in vivo changes of molecular targets in the striatum and the cerebral cortex

Haggkvist, J., Toth, M., Tari, L., Varnas, K., Svedberg, M., Forsberg, A., Nag, S., Dominguez, C., Munoz-Sanjuan, I., Bard, J., Wityak, J., Varrone, A., Halldin, C., Mrzljak, L.

Journal:

Journal of Nuclear Medicine

Year:

2016

Language:

english

File:

PDF, 1.19 MB

english, 2016

49

Section Review: Cardiovascular & Renal: Glycoprotein IIb/IIIa antagonists

Wityak, John, Sielecki, Thais M

Journal:

Expert Opinion on Therapeutic Patents

Year:

1996

Language:

english

File:

PDF, 1.26 MB

english, 1996

50

Longitudinal characterization of mGluR5 using 11 C-ABP688 PET imaging in the Q175 mouse model of Huntington's disease

Bertoglio, Daniele, Kosten, Lauren, Verhaeghe, Jeroen, Thomae, David, wyffels, Leonie, Stroobants, Sigrid, Wityak, John, Dominguez, Celia, Mrzljak, Ladislav, Staelens, Steven

Journal:

Journal of Nuclear Medicine

Year:

2018

Language:

english

File:

PDF, 1.17 MB

english, 2018

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